🩸 PLASMIC Score (TTP Probability)
Estimate the probability of thrombotic thrombocytopenic purpura (TTP) with the PLASMIC score.
PLASMIC Score (TTP Probability)
Platelet count < 30 ×10⁹/L
Haemolysis (retic > 2.5%, haptoglobin undetectable, or indirect bili > 2)
No active cancer
No solid-organ/stem-cell transplant
MCV < 90 fL
INR < 1.5
Creatinine < 2.0 mg/dL
When to use
Predict severe ADAMTS13 deficiency and prioritise plasma exchange.
How it works
Seven points (platelets, haemolysis, no cancer, no transplant, MCV, INR, creatinine). 0–4 low, 5 intermediate, 6–7 high probability.
Key points
- High scores predict severe ADAMTS13 deficiency (< 10%).
- Helps decide on empirical plasma exchange while ADAMTS13 is pending.
- Validated in adults with thrombotic microangiopathy.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.