🧬 Khorana Score (Chemotherapy VTE Risk)
Predict chemotherapy-associated VTE risk in ambulatory cancer patients (Khorana score).
Khorana Score (Chemotherapy VTE Risk)
Cancer site
Platelets ≥ 350 ×10⁹/L
Hb < 10 g/dL or using ESA
WBC > 11 ×10⁹/L
BMI ≥ 35 kg/m²
When to use
Decide on outpatient thromboprophylaxis during chemotherapy.
How it works
Cancer site (2/1/0) + platelets ≥ 350 (1) + Hb < 10/ESA (1) + WBC > 11 (1) + BMI ≥ 35 (1). ≥ 2 = high risk.
Key points
- Score ≥ 2 may prompt prophylaxis (apixaban/rivaroxaban/LMWH).
- Weigh against bleeding risk.
- Validated for ambulatory patients starting chemotherapy.
References
Decision support for licensed clinicians only; not a substitute for clinical judgement, diagnosis or local protocols.